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Acetoacetyl-CoA synthase

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Acetoacetyl-CoA synthase
Identifiers
EC no.2.3.1.194
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Acetoacetyl-CoA synthase (EC 2.3.1.194, NphT7) is an enzyme with systematic name acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating).[1] This enzyme catalyses the following chemical reaction

acetyl-CoA + malonyl-CoA acetoacetyl-CoA + CoA + CO2

The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA.

References

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  1. ^ Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T (June 2010). "Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway". Proceedings of the National Academy of Sciences of the United States of America. 107 (25): 11265–70. doi:10.1073/pnas.1000532107. PMC 2895072. PMID 20534558.
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